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Intraarterial Thrombolysis in Vertebrobasilar Occlusion AJNR 17:255-262, Becker,K.J.,et al, 1996 See this aricle in Pubmed Article Abstract The overall mortality was 75%.Recanalization could not be achieved in 3 of 13 treatments;all patients in whom recanalization failed died.The mortality rate was 60%in those patients in whom recanalization was successful.Coma or quadriparesis at the time of therapy uniformly predicted death.There were two cases each of bilateral proximal vertebral occlusions and midbasilar occlusions and nine cases of bilateral distal vertebral occlusions.There were three cases of fatal rethrombosis after initial successful thrombolysis.The mortality rate in the recanalized group before rethrombosis was 30%.There were two fatal hemorrhages of the central nervous system.Recanalization of the vertebrobasilar system is necessary but not sufficient for effective treatment of vertebrobasilar occlusive disease.The site of occlusion may help predict angiographic and clinical outcome.Time to initiation of thrombolysis is not an invariable correlate of survival,although clinical condition at presentation may be. Rethrombosis and hemorrhage are significant problems affecting mortality after successful thrombolysis.

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(click to filter results - removes previous filter) cerebrovascular accident cerebrovascular accident,acute management of cerebrovascular accident,thrombolytic agents in treatment fibrinolytic agents fibrinolytic agents,complications fibrinolytic agents,intra-arterial local infusion intracerebral hemorrhage prognosis recanalization,arterial treatment of neurologic disorder urokinase vertebral artery occlusion vertebral-basilar insufficiency

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